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Deep Vein Thrombosis in Refractory Erythema Nodosum Leprosum: A Report of Two Cases
Hansen's disease is a chronic granulomatous disease caused by Mycobacterium leprae. Acute exacerbations termed as lepra reactions often mark the course of the disease. These are of two types - Type 1 or Reversal Reaction and Type 2 or Erythema Nodosum Leprosum (ENL). Chronic recurrent ENL is a frequently encountered, difficult to treat condition which is usually managed with systemic corticosteroids, increasing the dose of clofazimine, non-steroidal anti-inflammatory drugs, cyclosporine A, azathioprine, pentoxyphylline, mycophenolate mofetil, methotrexate and intravenous immunoglobulin (IVIG). Thalidomide is the drug of choice in most instances. Thrombo-embolism is a rare but known complication of thalidomide therapy especially when combined with corticosteroids or chemotherapeutic agents. Herein we report 2 cases of refractory ENL developing Deep Vein Thrombosis (DVT) while on concomitant therapy with thalidomide and corticosteroids for the control of ENL.
Year of Publication
Indian Journal of Leprosy
Number of Pages