Dapsone Hypersensitivity Syndrome and Dapsone-induced Liver Injury in Four Malaysian Indigenous Individuals with Leprosy

Dapsone is part of the multi-drug therapy used in the treatment of leprosy. It can cause life-threatening hypersensitivity syndromes resulting in significant morbidity and mortality, especially among susceptible individuals such as those who are carriers of HLA-B*13:01 allele. Avoidance of dapsone in these susceptible individuals reduces the risk of dapsone-related adverse events. Herein, we report four indigenous patients with leprosy who developed dapsone hypersensitivity syndrome.