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Cyclooxygenase 2 and Vascular Endothelial Growth Factor - potential targets to manage lepra reactions: A case-control study.

Abstract

BACKGROUND: Reactions in leprosy have an immune mediated pathogenesis. While type 1 reactions are delayed hypersensitivity phenomenon, type 2 reactions are immune complex mediated. Key molecules which mediate the immune insult in lepra reactions require evaluation in order to tailor their therapy and prevent disability.

OBJECTIVE: To evaluate expressions of Cyclooxygenase 2 and Vascular Endothelial Growth Factor in skin biopsies from leprosy patients and correlate their expression with presence of either type 1 or type 2 lepra reactions.

METHODS: This was a case control study. Cyclooxygenase 2 and Vascular Endothelial Growth Factor expression in dermal macrophages and vascular endothelium was assessed immunohistochemically. Biopsies from patients with Non-reactive leprosy and healthy controls were used for comparison. SPSS software was used for statistical analysis.

RESULTS: A total of 147 skin biopsies were evaluated, including 18 with Type 1 reaction, 39 Type 2 reaction, 81 non-reactive leprosy and 9 healthy controls. Both Cyclooxygenase 2 and Vascular Endothelial Growth Factor expression were significantly higher in type 1 followed by type 2 reaction as compared to controls.

CONCLUSION: These results may guide us regarding use of Cyclooxygenase 2 and Vascular Endothelial Growth Factor inhibitor drugs which may be a major step in treating reactive leprosy patients and preventing nerve damage and disability. This article is protected by copyright. All rights reserved.

More information

Type
Journal Article
Author
Malhotra K
Suvirya S
Malhotra H
Kumar B
Kumar S
Husain N
Year of Publication
2021
Journal
Dermatologic therapy
Number of Pages
e14882
Date Published
02/2021
Language
eng
ISSN Number
1529-8019
DOI
10.1111/dth.14882
Alternate Journal
Dermatol Ther
PMID
33594711
Publication Language
eng