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Publication

Consanguinity and susceptibility to infectious diseases in humans.

Abstract

Studies of animal populations suggest that low genetic heterozygosity is an important risk factor for infection by a diverse range of pathogens, but relatively little research has looked to see whether similar patterns exist in humans. We have used microsatellite genome screen data for tuberculosis (TB), hepatitis and leprosy to test the hypothesis that inbreeding depression increases risk of infection. Our results indicate that inbred individuals are more common among our infected cases for TB and hepatitis, but only in populations where consanguineous marriages are common. No effect was found either for leprosy, which is thought to be oligogenic, or for hepatitis in Italy where consanguineous marriages are rare. Our results suggest that consanguinity is an important risk factor in susceptibility to infectious diseases in humans.

More information

Type
Journal Article
Author
Lyons EJ
Frodsham AJ
Zhang L
Hill AV S
Amos W
Year of Publication
2009
Journal
Biology letters
Volume
5
Issue
4
Number of Pages
574-6
Date Published
2009 Aug 23
Language
eng
ISSN Number
1744-957X
DOI
10.1098/rsbl.2009.0133
Alternate Journal
Biol. Lett.
Publication Language
eng