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[Comparative study between the Mitsuda test and the human leukocyte antigens in leprosy patients].

Abstract

In this study, we aimed to compare the Mitsuda skin test with the alleles HLA-DR2/HLA-DR3 and HLA-DQ1, in relation to the clinical forms of leprosy in 176 patients (50 TT, 50 LL and 76 B). The results obtained did not reveal any association between the Mitsuda reaction and the HLA alleles in the clinical forms isolated. However, when analyzed according to Mitsuda test response, a significant association was found between patients with negative Mitsuda reaction and HLA-DQ1 (p=0.002). No association was observed between positive Mitsuda reaction and the HLA-DR2/DR3 alleles. We concluded that the allele HLA-DQ1 has an important participation when there is no response to the Mitsuda test. We suggest that more specific studies should be developed on this allele.

More information

Type
Journal Article
Author
Souza FC
Marcos EVC
Ura S
Opromolla PA
Nogueira MES
Year of Publication
2007
Journal
Revista da Sociedade Brasileira de Medicina Tropical
Volume
40
Issue
2
Number of Pages
188-91
Date Published
2007 Mar-Apr
Language
por
ISSN Number
0037-8682
DOI
10.1590/s0037-86822007000200008
Alternate Journal
Rev. Soc. Bras. Med. Trop.
Publication Language
por

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