Back to search
Publication

Atopy and IgE in patients with leprosy.

Abstract

The atopic status of patients with leprosy was assessed by medical history, physical examination, serum total IgE, and specific IgE antibodies to common allergens (by skin testing and RAST). Tests for specific IgE antibody to Mycobacterium leprae were performed by RAST and immunoblotting technique. We studied 28 patients with leprosy and 49 control subjects. The two groups did not differ significantly in the prevalence of atopic disease. The IgE level was significantly higher in the patients, however, than in the control subjects, whether there was atopy (296.1 versus 96.3 IU/ml) or not atopy (72.9 versus 18.9 IU/ml). Neither RAST nor immunoblotting technique detected significant levels of IgE antibodies to M. leprae. Our data indicate that leprosy was associated with increased total IgE level, but clinical atopy in patients with leprosy was similar to that in control subjects. The observed IgE increase in patients with leprosy appears to be generally nonspecific.

More information

Type
Journal Article
Author
Smith D L
Bahna S L
Gillis T P
Clements B H
Year of Publication
1990
Journal
The Journal of allergy and clinical immunology
Volume
85
Issue
4
Number of Pages
795-800
Date Published
1990 Apr
Language
eng
ISSN Number
0091-6749
DOI
10.1016/0091-6749(90)90201-e
Alternate Journal
J. Allergy Clin. Immunol.
Publication Language
eng