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Publication

The AFIP history of ocular leprosy.

Abstract

Purpose: To investigate the Armed Forces Institute of Pathology (AFIP) experience with Ocular Leprosy.

Methods: The AFIP data banks were screened for cases with diagnosis of ocular leprosy. Files and slides stained with Hematoxylin-eosin and acid-fast staining were reviewed by the Division of Ocular Pathology and by the Infectious Diseases Pathology Branch.

Results: Twenty-five cases were found from 1951 to 1985 and there were 15 males and 7 females and in 3 cases the sex was not given. The disease process ran from 4 months to 50 years in this series. Three patients also had systemic mycobacterium tuberculosis infections. The clinical manifestations of leprosy did not correlate with the histopathological findings. Clinically, corneal manifestations were the most common clinical presentation in 15 cases with only one perforation, iridocyclitis following in 9 patients and eyelid abnormalities ranging from ectropion to trichiasis in 7 patients. Two patients at autopsy had lepromatous cells in the ciliary body as the only ocular manifestation.

Conclusions: In summary, this paper represents a series of ocular leprosy cases from the AFIP which shows the severity of ocular involvement, the predilection of anterior segment involvement and a large number of histopathologic indeterminate cases. The current immigrant and refugee crisis warrants revisting this ancient disease in the differential diagnosis.

More information

Type
Journal Article
Author
Wroblewski K
Hidayat A
Neafie R
Meyers W
Year of Publication
2019
Journal
Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
Volume
33
Issue
3
Number of Pages
255-259
Date Published
01/2019
Language
eng
ISSN Number
1319-4534
DOI
10.1016/j.sjopt.2019.09.003
Alternate Journal
Saudi J Ophthalmol
PMID
31686967
Publication Language
eng