Introduction
Before multidrug therapy (MDT) was introduced in the 1980s leprosy was treated with dapsone monotherapy. Resistance to dapsone has been reported since the early 1960s. Rifampicin is the main component of MDT for leprosy. It is therefore important to monitor the emergence of rifampicin-resistant strains. Fluoroquinolones are advised in case of rifampicin resistance. Clofazimine resistance is still rare.
Related publications(s)
Publication
A guide for surveillance of antimicrobial resistance in leprosy: 2017 update
Cooreman EA.
World Health Organization.
2017;
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Publication
Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-2015.
Cambau E, Saunderson P, Matsuoka M, et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2018;
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Publication
Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae.
Benjak A, Avanzi C, Singh P, et al.
Nature communications.
2018;
9 (1) : 352.
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Publication
Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy.
Mieras L, Anthony R, van Brakel WH, et al.
Infectious diseases of poverty.
2016;
5 (1) : 46.
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Publication
Drug-resistance in leprosy: moving toward understanding the scope of the problem and how to tackle it.
Moraes MO.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2016;
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Publication
Resistance to anti leprosy drugs in multi-bacillary leprosy: A cross sectional study from a tertiary care centre in eastern Uttar Pradesh, India.
Singh SK, Kumar A, Nath G, et al.
Indian journal of dermatology, venereology and leprology.
2018;
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Publication
Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 200-9-15. Cambau, Saunderson, Matsuoka, Cole et al.
Lockwood D, Walker S.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2018;