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Ultrastructural alterations of mycobacterium leprae in skin biopsies of untreated and treated lepromatous patients.
Abstract
1. -- Mycobacterium leprae cells under a process of progressive disaggregation are present in the skin of both treated and untreated patients. 2. -- The ultrastructural alterations observed during the degenerative process seem to be qualitatively similar in treated and untreated patients. 3. -- The proportion of altered M. leprae cells increases during the treatment, mainly with rifampicin and rifampicin + clofazimine + diaminodiphenyl sulfone. 4. -- The cell wall of M. leprae is the last bacterial structure to disappear during the degenerative process.
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Type
Journal Article