|Title||Tuberculosis treatment unmasking leprosy: management of drug-resistant tuberculosis and leprosy co-infection.|
|Publication Type||Journal Article|
|Authors||Kama G, Huang GKL, Taune M, Arura R, Morris L, Kombuk B, Marome A, O'Brien DP|
|Abbrev. Journal||Public Health Action|
|Journal||Public health action|
|Year of Publication||2019|
Co-infection with tuberculosis (TB) and leprosy is thought to occur infrequently, but has been reported in settings highly endemic for both infectious diseases. We report for the first time a case where treatment for multidrug-resistant TB (MDR-TB) led to the 'unmasking' of clinically silent leprosy through the precipitation of a type-1 immunological reaction. Current treatment regimens for MDR-TB may contain a number of drugs, such as levo-floxacin and clofazimine, which also have activity against M. leprae. A treatment regimen containing drugs active against both mycobacterial species may be used to achieve cure. Individual considerations on drug-drug interactions, potential additive toxicities and other comorbidities should be taken into account.
|PubMed Central ID||PMC6735462|