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In silico analysis of novel mutations determined within RRDR region of rpoB gene of M. leprae: A possible cause of Rifampicin resistance among leprosy patients

Abstract

In silico methods help in understanding the role of mutations in gene sequences through bioinformatics tools and can help in the identification of therapeutic targets. This study determined, the binding interactions of Rifampicin, a chemotherapeutic drug commonly used in Multidrug Therapy (MDT) for treatment of leprosy, against the rpoB models bearing point mutations. Using Molegro Virtual Docker we analyzed 4 novel mutations within Rifampicin Resistance Determining Region (RRDR) of rpoB gene of M.leprae which could confer resistance to Rifampicin, revealed that mutations causing structural modifications modulated the drug binding energies with receptor.

 

 

More information

Type
Journal Article
Author
Nigam A
Lavania M
Singh I
Turankar R