[The protective efficacy of BCG against leprosy in São Paulo, Brazil].

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Title[The protective efficacy of BCG against leprosy in São Paulo, Brazil].
Publication TypeJournal Article
AuthorsLombardi C, Pedrazzani ES, Pedrazzani JC, Ferreira Filho P, Zicker F
Abbrev. JournalBol Oficina Sanit Panam
JournalBoletin de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau
Year of Publication1995
Volume119
Issue5
Pagination415-21
Publication Languagespa
KeywordsAdolescent, BCG Vaccine, Brazil, Case-Control Studies, Child, Drug Evaluation, Female, Humans, Leprosy, Male, Statistics as Topic
Abstract

The protection against leprosy conferred by BCG vaccination was evaluated in a case-control study. Selected for the study were 97 patients under 16 years of age who had been diagnosed with leprosy (cases) and 385 healthy persons (controls), who were matched according to sex, age, place of residence, and type of contact (intra- or extradomicilliary). The cases were selected from a register of active cases as well as a series of new leprosy patients treated in 50 centers in the city of São Paulo, Brasil. To estimate the protective effect of BCG, the prevalences of BCG scars among cases and controls were compared. The presence of one or more scars was associated with a protective efficacy of 90% (95% confidence interval: 78%-96%). Stratified analysis by age group, sex, socioeconomic level, and clinical form of leprosy did not reveal any important differences in the protection conferred by the vaccine. The significance of these findings and the appropriateness of using BCG in leprosy control programs is discussed.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/8540997?dopt=Abstract