Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil.

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TitleInfluence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil.
Publication TypeJournal Article
AuthorsJarduli LR, Alves HV, de Souza-Santana FC, Marcos EVC, Pereira AC, Dias-Baptista IMF, Fava VM, Mira MT, Moraes MO, da Virmond MCL, Visentainer JEL
Abbrev. JournalBMC Infect. Dis.
JournalBMC infectious diseases
Year of Publication2014
Volume14
Issue1
Pagination438
Publication Languageeng
KeywordsBrazil, KIR genes, Leprosy, NK cells
Abstract

BACKGROUND: The objective of this study was to investigate the association between KIR genes and the immunopathogenesis of leprosy.

METHODS: The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and 413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher's exact test and stepwise multivariate analysis.

RESULTS: There was a higher frequency of activating KIR genes (KIR2DS1, 2DS2 and 3DS1) together with their HLA ligands in the tuberculoid (TT) group as compared to the lepromatous leprosy (LL) group. KIR2DL2/2DL2-C1 was more frequent in the patient, TT and LL groups than in the control group. Borderline patients presented a higher frequency of inhibitory pairs when compared to the control group, and a higher frequency of activating pairs as compared to the LL group. Multivariate analysis confirmed the associations and demonstrated that being a female is a protective factor against the development of the disease per se and the more severe clinical form.

CONCLUSIONS: This study showed that activating and inhibitory KIR genes may influence the development of leprosy - in particular, activating genes may protect against the more aggressive form of the disease - thereby demonstrating the role of NK cells in the immunopathology of the disease.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/25117794?dopt=Abstract

DOI10.1186/1471-2334-14-438
Link to full texthttp://www.biomedcentral.com/content/pdf/1471-2334-14-438.pdf
PubMed Central IDPMC4141108