Geographic distribution, age pattern and sites of lesions in a cohort of Buruli ulcer patients from the Mapé Basin of Cameroon.

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TitleGeographic distribution, age pattern and sites of lesions in a cohort of Buruli ulcer patients from the Mapé Basin of Cameroon.
Publication TypeJournal Article
AuthorsBratschi MW, Bolz M, Minyem JC, Grize L, Wantong FG, Kerber S, Njih Tabah E, Ruf M-T, Mou F, Noumen D, Um Boock A, Pluschke G
Abbrev. JournalPLoS Negl Trop Dis
JournalPLoS neglected tropical diseases
Year of Publication2013
Volume7
Issue6
Paginatione2252
Publication Languageeng
KeywordsAdolescent, Adult, Age Factors, Aged, Buruli Ulcer, Cameroon, Child, Child, Preschool, Cohort Studies, Cross-Sectional Studies, Female, Humans, Infant, Male, Middle Aged, Mycobacterium ulcerans, Risk Factors, Topography, Medical, Young Adult
Abstract

Buruli ulcer (BU), a neglected tropical disease of the skin, caused by Mycobacterium ulcerans, occurs most frequently in children in West Africa. Risk factors for BU include proximity to slow flowing water, poor wound care and not wearing protective clothing. Man-made alterations of the environment have been suggested to lead to increased BU incidence. M. ulcerans DNA has been detected in the environment, water bugs and recently also in mosquitoes. Despite these findings, the mode of transmission of BU remains poorly understood and both transmission by insects or direct inoculation from contaminated environment have been suggested. Here, we investigated the BU epidemiology in the Mapé basin of Cameroon where the damming of the Mapé River since 1988 is believed to have increased the incidence of BU. Through a house-by-house survey in spring 2010, which also examined the local population for leprosy and yaws, and continued surveillance thereafter, we identified, till June 2012, altogether 88 RT-PCR positive cases of BU. We found that the age adjusted cumulative incidence of BU was highest in young teenagers and in individuals above the age of 50 and that very young children (

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/23785529?dopt=Abstract

DOI10.1371/journal.pntd.0002252
Link to full texthttp://journals.plos.org/plosntds/article/asset?id=10.1371%2Fjournal.pntd.0002252.PDF
PubMed Central IDPMC3681622