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Genome-wide re-sequencing of multi-drug resistant Mycobacterium leprae Airaku-3.

Abstract

Genotyping and molecular characterization of drug resistance mechanisms in Mycobacterium leprae enables disease transmission and drug resistance trends to be monitored. In the present study, we performed genome-wide analysis of Airaku-3, a multidrug resistant strain with an unknown mechanism of resistance to rifampicin. We identified 12 unique non-synonymous single-nucleotide polymorphisms (SNPs) including two in the transporter-encoding ctpC and ctpI genes. In addition, two SNPs were found that improve the resolution of SNP-based genotyping, particularly for Venezuelan and South-East Asian strains of M. leprae. This article is protected by copyright. All rights reserved.

More information

Type
Journal Article
Author
Singh P
Benjak A
Carat S
Kai M
Busso P
Avanzi C
Paniz-Mondolfi A
Peter C
Harshman K
Rougemont J
Matsuoka M
Cole S

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