Epidemiologic study of 107 cases of families with leprosy in Duque de Caxias, Rio de Janeiro, Brazil.

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TitleEpidemiologic study of 107 cases of families with leprosy in Duque de Caxias, Rio de Janeiro, Brazil.
Publication TypeJournal Article
AuthorsDurães SMB, Guedes LS, da Cunha MD, Magnanini MMF, de Oliveira MLWDR
Abbrev. JournalAn Bras Dermatol
JournalAnais brasileiros de dermatologia
Year of Publication2010
Volume85
Issue3
Pagination339-45
Publication Languageeng
KeywordsAdult, Brazil, Female, Humans, Leprosy, Male, Middle Aged, Pedigree, Risk Factors
Abstract

BACKGROUNDS: ultibacillary patients are the major source of infection in leprosy. Nevertheless, the risk is higher in household contacts between multibacillary patients than paucibacillary patients and in the general population. Household contacts are in close genetic relationship with the index case-patient.

OBJECTIVE: To evaluate epidemiological data of the following variables: age, gender, education level, genetic proximity, and type of contact with the index case-patient (household or not) in 107 families with leprosy.

METHODS: Home visits were conducted to clinically examine family members. The medical charts of index case-patients and co-prevalent cases were reviewed.

RESULTS: The controlled analysis of variables such as type of contact and genetic proximity revealed that household contacts and first-degree kinship are independently associated with a higher chance of contracting the disease.

CONCLUSION: Household contacts are often genetically closer to the index case-patient. To investigate the independent relevance of these risks in leprosy surveillance contact studies has been a challenge. Our results confirm literature data that show the influence of genetics in the susceptibility to leprosy per se.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/20676467?dopt=Abstract

DOI10.1590/s0365-05962010000300007
Link to full texthttp://www.scielo.br/pdf/abd/v85n3/en_a07v85n3.pdf