Dermatopathology: LC07-1 CUTANEOUS XANTHOMATOUS INFILTRATE.

Xanthomatous infiltrate indicates aggregation of foamy histiocytes in the dermis. It may show nodular, interstitial, diffuse, perivascular, perifollicular pattern and corresponds to various disorders, including neoplasm, deposition, inflammation, and infection. Usually xanthomatous infiltrate represents hyperlipidemic xanthoma, such as eruptive xanthoma, tuberous xanthoma, and xanthelasma. They can be also seen in normolipidemic conditions, including diffuse plane xanthoma, papular xanthoma, and verruciform xanthoma. Xanthomatous infiltrate can also be seen in certain infectious diseases, especially lepromatous leprosy. This lecture reviews and summarizes various conditions of cutaneous xanthomatous infiltrate and emphasizes the diagnostic pitfalls in different settings.