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Complement in neuroinflammation : Studies in leprosy and Amyotrophic Lateral Sclerosis

Abstract

The complement system is a part of the innate immunity, and plays an important role in host immunity and inflammation. We previously identified the terminal membrane attack complex (MAC) of the complement system as a key determinant of neurodegeneration and demonstrated that its inhibition is neuroprotective. Besides being part of a mechanism of defence to invading pathogens, MAC has the capacity to cause damage to self-cells and is consequently implicated in many diseases.

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Thesis

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