Leprosy reaction as a manifestation of immune reconstitution inflammatory syndrome: a case series of a Brazilian cohort.

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TítuloLeprosy reaction as a manifestation of immune reconstitution inflammatory syndrome: a case series of a Brazilian cohort.
Tipo de PublicaçãoJournal Article
AutoresMenezes VM, Sales AM, Illarramendi X, Miranda A, Gonçalves Morgado M, Gutierrez-Galhardo MC, Nunes Sarno E, da Costa Nery JA
Abbrev. JournalAIDS
RevistaAIDS (London, England)
Ano de Publicação2009
Volume23
Issue5
Pagination641-3
Idioma da Publicaçãoeng
Palavras-chave Adult, Antiretroviral Therapy, Highly Active, Cohort Studies, Female, HIV Infections, Humans, Immune Reconstitution Inflammatory Syndrome, Leprosy, Male, Middle Aged, Young Adult
Resumo

Several case reports have demonstrated that the immune reconstitution inflammatory syndrome induces reversal reaction in HIV and leprosy-coinfected patients. The present study describes 10 cases of immune reconstitution inflammatory-associated reversal reaction. The patients evolved satisfactorily despite presenting a more severe form of the disease and the fact that three required an additional use of corticoids. The present study, the largest case series published to date, demonstrates that leprosy reaction is a manifestation of immune reconstitution.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/19525622?dopt=Abstract

DOI10.1097/QAD.0b013e3283291405