TY - JOUR
KW - Cross Reactions
KW - HLA Antigens
KW - HLA-A Antigens
KW - HLA-B Antigens
KW - HLA-DQ Antigens
KW - HLA-DR Antigens
KW - Humans
KW - Immunophenotyping
KW - Lepromin
KW - leprosy
KW - Mycobacterium
KW - Vaccines, Inactivated
AU - Rani R
AU - Zaheer S A
AU - Suresh N R
AU - Walia R
AU - Parida S K
AU - Mukherjee A
AU - Mukherjee R
AU - Talwar G P
AB - <p>Leprosy patients undergoing phase II trials in two hospitals of New Delhi, India, were HLA typed to see the association of HLA with differential responsiveness to Mycobacterium w vaccine. The vaccine comprises an atypical, nonpathogenic mycobacterium, Mycobacterium w, which has cross-reactive antigens with M. leprae. Multibacillary patients who are lepromin negative are vaccinated at an interval of 3 months. Considerable improvement is evident in the patients in terms of a decline in bacterial indices and histopathological and immunological upgrading. But all the patients do not respond to the vaccine in the same manner; some are slow responders, while others are good responders. HLA-A28 and DQw3 (DQw8 + 9) were found to be associated with slow responsiveness, while DQw1 and DQw7 were found to be associated with a more rapid responsiveness to the M. w vaccine. However, these associations were not significant after P correction for the number of antigens tested for each locus except for HLA-DQw3 (DQw8 and DQw9) and DQw7. DQw7, a new defined split of HLA-DQw3, seems to be associated with the responsiveness to M. w vaccine.</p>
BT - Journal of clinical immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/1551942?dopt=Abstract
DA - 1992 Jan
DO - 10.1007/bf00918273
IS - 1
J2 - J. Clin. Immunol.
LA - eng
N2 - <p>Leprosy patients undergoing phase II trials in two hospitals of New Delhi, India, were HLA typed to see the association of HLA with differential responsiveness to Mycobacterium w vaccine. The vaccine comprises an atypical, nonpathogenic mycobacterium, Mycobacterium w, which has cross-reactive antigens with M. leprae. Multibacillary patients who are lepromin negative are vaccinated at an interval of 3 months. Considerable improvement is evident in the patients in terms of a decline in bacterial indices and histopathological and immunological upgrading. But all the patients do not respond to the vaccine in the same manner; some are slow responders, while others are good responders. HLA-A28 and DQw3 (DQw8 + 9) were found to be associated with slow responsiveness, while DQw1 and DQw7 were found to be associated with a more rapid responsiveness to the M. w vaccine. However, these associations were not significant after P correction for the number of antigens tested for each locus except for HLA-DQw3 (DQw8 and DQw9) and DQw7. DQw7, a new defined split of HLA-DQw3, seems to be associated with the responsiveness to M. w vaccine.</p>
PY - 1992
SP - 50
EP - 5
T2 - Journal of clinical immunology
TI - Association of HLA antigens with differential responsiveness to Mycobacterium w vaccine in multibacillary leprosy patients.
VL - 12
SN - 0271-9142
ER -