TY - JOUR KW - Adolescent KW - Adult KW - Aged KW - Bacterial Vaccines KW - Child KW - Child, Preschool KW - Humans KW - Infant KW - Lepromin KW - leprosy KW - Middle Aged KW - Mycobacterium KW - Skin Tests KW - Vaccination AU - Kar H K AU - Sharma A K AU - Misra R S AU - Zaheer S A AU - Mukherjee A AU - Mukherjee R AU - Beena K R AU - Kaur H AU - Nair S K AU - Talwar G P AB -

In a hospital based study, 362 household contacts of multibacillary leprosy patients were screened for evidence of leprosy and 54 (14.9%) were found to be having leprosy. The remaining 308 apparently healthy contacts were lepromin tested and 109 (35.4%) were observed to be negative to Mitsuda lepromin. M.w vaccine was administered intradermally to 95 of these 109 lepromin negative contacts. Sixty eight of them could be retested for lepromin A reactivity. Fifty six (82.35%) manifested lepromin conversion. The twelve subjects who did not show lepromin conversion, received a second dose of the vaccine, and eleven subsequently became lepromin positive. The overall lepromin conversion rate was thus 98.5% (67 out of 68). Follow-up of these contacts upto a period of 30 months did not demonstrate reversion of lepromin positivity back to negativity status. No untoward effects of vaccination were observed except for local ulceration at the site of vaccine administration.

BT - Indian journal of leprosy C1 - http://www.ncbi.nlm.nih.gov/pubmed/1308525?dopt=Abstract CN - Infolep Library - available DA - 1992 Oct-Dec IS - 4 J2 - Indian J Lepr LA - eng N2 -

In a hospital based study, 362 household contacts of multibacillary leprosy patients were screened for evidence of leprosy and 54 (14.9%) were found to be having leprosy. The remaining 308 apparently healthy contacts were lepromin tested and 109 (35.4%) were observed to be negative to Mitsuda lepromin. M.w vaccine was administered intradermally to 95 of these 109 lepromin negative contacts. Sixty eight of them could be retested for lepromin A reactivity. Fifty six (82.35%) manifested lepromin conversion. The twelve subjects who did not show lepromin conversion, received a second dose of the vaccine, and eleven subsequently became lepromin positive. The overall lepromin conversion rate was thus 98.5% (67 out of 68). Follow-up of these contacts upto a period of 30 months did not demonstrate reversion of lepromin positivity back to negativity status. No untoward effects of vaccination were observed except for local ulceration at the site of vaccine administration.

PY - 1992 SP - 495 EP - 500 T2 - Indian journal of leprosy TI - Induction of lepromin positivity by a candidate anti-leprosy vaccine Mycobacterium w in lepromin negative healthy contacts of multibacillary leprosy patients. VL - 64 SN - 0254-9395 ER -