TY - JOUR
KW - Animals
KW - Bacterial Vaccines
KW - Disease Models, Animal
KW - leprosy
KW - Mice
KW - Mice, Inbred Strains
KW - Sensitivity and Specificity
KW - Vaccines, Subunit
AU - Britton W J
AU - Martin E
AU - Kamath A T
AU - Neupane K D
AU - Roche P W
AB - <p>We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and the immunodominant 35 kDa protein of M. leprae as the candidate antigen. A DNA vaccine that expresses the M. leprae 35 kDa protein both stimulated interferon-gamma (IFN gamma)-secreting T cells in mice, and demonstrated protection against M. leprae-infection of mice.</p>
BT - Leprosy review
C1 - http://www.ncbi.nlm.nih.gov/pubmed/11201878?dopt=Abstract
CN - Infolep Library - available
DA - 2000 Dec
J2 - Lepr Rev
LA - eng
N2 - <p>We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and the immunodominant 35 kDa protein of M. leprae as the candidate antigen. A DNA vaccine that expresses the M. leprae 35 kDa protein both stimulated interferon-gamma (IFN gamma)-secreting T cells in mice, and demonstrated protection against M. leprae-infection of mice.</p>
PY - 2000
SP - S176
EP - 81
T2 - Leprosy review
TI - Immunoprophylaxis against Mycobacterium leprae infection with subunit vaccines.
UR - http://leprev.ilsl.br/pdfs/2000/v71s1/pdf/v71s1a34.pdf
VL - 71 Suppl
SN - 0305-7518
ER -