01487nas a2200349   4500000000100000008004100001260001300042653002300055653003000078653003000108653001100138653001300149653002300162653002500185653000900210653001600219653002500235100001500260700001500275700001200290700001500302700001600317700001600333700001500349245012200364856005900486300001200545490000700557050003200564520052700596022001401123       1991                            d  c1991 Sep10aBacterial Vaccines10aCombined Modality Therapy10aDrug Therapy, Combination10aHumans10aLepromin10aLeprostatic Agents10aLeprosy, lepromatous10aMale10aMiddle Aged10aMycobacterium leprae1 aZaheer S A1 aSuresh N R1 aKar H K1 aSharma A K1 aMukherjee A1 aMukherjee R1 aTalwar G P00aImmunological upgrading with combined immunotherapy and chemotherapy in a lepromatous leprosy patient: a case report.  uhttp://leprev.ilsl.br/pdfs/1991/v62n3/pdf/v62n3a08.pdf  a297-3020 v62  aInfolep Library - available3 a<p>Immunotherapy with Mycobacterium w was given, in addition to standard multidrug therapy (MDT) to a lepromatous leprosy (LL) patient with a bacteriological index (BI) of 6. After 15 months of treatment this patient attained bacteriological negativity and clinical inactivity. Histopathologically the patient upgraded to borderline-tuberculoid at 12 months, and at 15 months showed features of nonspecific infiltration in the dermis. The rapid immunological upgrading seen in the patient is highlighted in this paper.</p>  a0305-7518