02057nas a2200361   4500000000100000008004100001260001300042653002000055653001700075653001900092653001900111653002000130653002000150653001100170653002200181653001300203653001200216653001800228653002600246100001100272700001500283700001500298700001200313700001500325700001600340700001600356700001500372245012800387300000900515490000700524520115000531022001401681       1992                            d  c1992 Jan10aCross Reactions10aHLA Antigens10aHLA-A Antigens10aHLA-B Antigens10aHLA-DQ Antigens10aHLA-DR Antigens10aHumans10aImmunophenotyping10aLepromin10aleprosy10aMycobacterium10aVaccines, Inactivated1 aRani R1 aZaheer S A1 aSuresh N R1 aWalia R1 aParida S K1 aMukherjee A1 aMukherjee R1 aTalwar G P00aAssociation of HLA antigens with differential responsiveness to Mycobacterium w vaccine in multibacillary leprosy patients.  a50-50 v123 a<p>Leprosy patients undergoing phase II trials in two hospitals of New Delhi, India, were HLA typed to see the association of HLA with differential responsiveness to Mycobacterium w vaccine. The vaccine comprises an atypical, nonpathogenic mycobacterium, Mycobacterium w, which has cross-reactive antigens with M. leprae. Multibacillary patients who are lepromin negative are vaccinated at an interval of 3 months. Considerable improvement is evident in the patients in terms of a decline in bacterial indices and histopathological and immunological upgrading. But all the patients do not respond to the vaccine in the same manner; some are slow responders, while others are good responders. HLA-A28 and DQw3 (DQw8 + 9) were found to be associated with slow responsiveness, while DQw1 and DQw7 were found to be associated with a more rapid responsiveness to the M. w vaccine. However, these associations were not significant after P correction for the number of antigens tested for each locus except for HLA-DQw3 (DQw8 and DQw9) and DQw7. DQw7, a new defined split of HLA-DQw3, seems to be associated with the responsiveness to M. w vaccine.</p>  a0271-9142