02037nas a2200421   4500000000100000008004100001260001700042653001500059653001000074653000900084653002300093653001000116653002100126653001100147653001100158653001300169653001200182653001600194653001800210653001500228653001600243100001200259700001500271700001400286700001500300700001600315700001600331700001400347700001100361700001300372700001500385245016300400300001200563490000700575050003200582520098700614022001401601       1992                            d  c1992 Oct-Dec10aAdolescent10aAdult10aAged10aBacterial Vaccines10aChild10aChild, Preschool10aHumans10aInfant10aLepromin10aleprosy10aMiddle Aged10aMycobacterium10aSkin Tests10aVaccination1 aKar H K1 aSharma A K1 aMisra R S1 aZaheer S A1 aMukherjee A1 aMukherjee R1 aBeena K R1 aKaur H1 aNair S K1 aTalwar G P00aInduction of lepromin positivity by a candidate anti-leprosy vaccine Mycobacterium w in lepromin negative healthy contacts of multibacillary leprosy patients.  a495-5000 v64  aInfolep Library - available3 a<p>In a hospital based study, 362 household contacts of multibacillary leprosy patients were screened for evidence of leprosy and 54 (14.9%) were found to be having leprosy. The remaining 308 apparently healthy contacts were lepromin tested and 109 (35.4%) were observed to be negative to Mitsuda lepromin. M.w vaccine was administered intradermally to 95 of these 109 lepromin negative contacts. Sixty eight of them could be retested for lepromin A reactivity. Fifty six (82.35%) manifested lepromin conversion. The twelve subjects who did not show lepromin conversion, received a second dose of the vaccine, and eleven subsequently became lepromin positive. The overall lepromin conversion rate was thus 98.5% (67 out of 68). Follow-up of these contacts upto a period of 30 months did not demonstrate reversion of lepromin positivity back to negativity status. No untoward effects of vaccination were observed except for local ulceration at the site of vaccine administration.</p>  a0254-9395