01256nas a2200217   4500000000100000008004100001653002700042653001200069653001100081653002300092653002200115653001300137100001100150700001000161700001000171245004700181300001300228490000700241520077600248022001401024       2013                            d10aAdjuvants, Immunologic10aAnimals10aHumans10aImmunity, Cellular10aInfection Control10aVaccines1 aReed S1 aOrr M1 aFox C00aKey roles of adjuvants in modern vaccines.  a1597-6080 v193 a<p>Vaccines containing novel adjuvant formulations are increasingly reaching advanced development and licensing stages, providing new tools to fill previously unmet clinical needs. However, many adjuvants fail during product development owing to factors such as manufacturability, stability, lack of effectiveness, unacceptable levels of tolerability or safety concerns. This Review outlines the potential benefits of adjuvants in current and future vaccines and describes the importance of formulation and mechanisms of action of adjuvants. Moreover, we emphasize safety considerations and other crucial aspects in the clinical development of effective adjuvants that will help facilitate effective next-generation vaccines against devastating infectious diseases.</p>
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