01234nas a2200301   4500000000100000008004100001260001300042653001200055653002300067653002700090653001200117653000900129653002500138653003200163653002200195100001600217700001300233700001500246700001600261700001400277245008400291856005900375300001200434490001300446050003200459520042700491022001400918       2000                            d  c2000 Dec10aAnimals10aBacterial Vaccines10aDisease Models, Animal10aleprosy10aMice10aMice, Inbred Strains10aSensitivity and Specificity10aVaccines, Subunit1 aBritton W J1 aMartin E1 aKamath A T1 aNeupane K D1 aRoche P W00aImmunoprophylaxis against Mycobacterium leprae infection with subunit vaccines.  uhttp://leprev.ilsl.br/pdfs/2000/v71s1/pdf/v71s1a34.pdf  aS176-810 v71 Suppl  aInfolep Library - available3 a<p>We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and the immunodominant 35 kDa protein of M. leprae as the candidate antigen. A DNA vaccine that expresses the M. leprae 35 kDa protein both stimulated interferon-gamma (IFN gamma)-secreting T cells in mice, and demonstrated protection against M. leprae-infection of mice.</p>  a0305-7518