01817nas a2200397   4500000000100000008004100001260001300042653003100055653002400086653002600110653002400136653000800160653002500168653003800193653001100231653002900242653002000271653003400291653002500325653002100350653002300371653003000394653002300424100001500447700001200462700001400474700001600488700001300504700001500517700001700532245007000549300001300619490000700632520076600639022001401405       1988                            d  c1988 Sep10aAntibodies, Anti-Idiotypic10aAntigens, Bacterial10aArthritis, Rheumatoid10aAutoimmune Diseases10aDNA10aDNA, Single-Stranded10aEnzyme-Linked Immunosorbent Assay10aHumans10aImmunoglobulin Idiotypes10aImmunoglobulins10aLupus Erythematosus, Systemic10aMycobacterium leprae10aReference Values10aRheumatic Diseases10aSeverity of Illness Index10aSjogren's Syndrome1 aWilliams W1 aZumla A1 aBehrens R1 aLocniskar M1 aVoller A1 aMcAdam K P1 aIsenberg D A00aStudies of a common idiotype PR4 in autoimmune rheumatic disease.  a1097-1040 v313 a<p>A new common idiotype, designated PR4, is described. This idiotype was originally identified on a human hybridoma-derived monoclonal antibody from a patient with leprosy, which binds the major Mycobacterium leprae-derived antigen, phenolic glycolipid-1, poly(ADP)-ribose, DNA, and poly(dT). The PR4 idiotype was found in patients with systemic lupus erythematosus (SLE) (70%), rheumatoid arthritis (40%), and Sjögren's syndrome (15%). It was not, however, found in the spouses of the SLE patients or (unlike other lupus idiotypes) in their healthy first-degree relatives. Although no correlation between PR4 idiotype levels and disease activity in SLE was found, a subset of rheumatoid arthritis patients with high levels of the idiotype was identified.</p>  a0004-3591