@article{6435,
  keywords = {Cross Reactions, HLA Antigens, HLA-A Antigens, HLA-B Antigens, HLA-DQ Antigens, HLA-DR Antigens, Humans, Immunophenotyping, Lepromin, leprosy, Mycobacterium, Vaccines, Inactivated},
  author = {Rani R and Zaheer S A and Suresh N R and Walia R and Parida S K and Mukherjee A and Mukherjee R and Talwar G P},
  title = {Association of HLA antigens with differential responsiveness to Mycobacterium w vaccine in multibacillary leprosy patients.},
  abstract = {<p>Leprosy patients undergoing phase II trials in two hospitals of New Delhi, India, were HLA typed to see the association of HLA with differential responsiveness to Mycobacterium w vaccine. The vaccine comprises an atypical, nonpathogenic mycobacterium, Mycobacterium w, which has cross-reactive antigens with M. leprae. Multibacillary patients who are lepromin negative are vaccinated at an interval of 3 months. Considerable improvement is evident in the patients in terms of a decline in bacterial indices and histopathological and immunological upgrading. But all the patients do not respond to the vaccine in the same manner; some are slow responders, while others are good responders. HLA-A28 and DQw3 (DQw8 + 9) were found to be associated with slow responsiveness, while DQw1 and DQw7 were found to be associated with a more rapid responsiveness to the M. w vaccine. However, these associations were not significant after P correction for the number of antigens tested for each locus except for HLA-DQw3 (DQw8 and DQw9) and DQw7. DQw7, a new defined split of HLA-DQw3, seems to be associated with the responsiveness to M. w vaccine.</p>},
  year = {1992},
  journal = {Journal of clinical immunology},
  volume = {12},
  pages = {50-5},
  month = {1992 Jan},
  issn = {0271-9142},
  doi = {10.1007/bf00918273},
  language = {eng},
}