@article{30856,
  keywords = {Type 1 reaction, leprosy, IP10, Borderline leprosy},
  author = {Pujiastuti AT and Agusni I and Rahmadewi R},
  title = {[Profile of Serum Interferon Gamma Induced Protein 10 in Borderline Leprosy Patients with and without Type 1 Leprosy Reaction]},
  abstract = {<p><strong>Background: </strong>Leprosy reaction is an acute episode in leprosy characterized by acute inflammation sometimes accompanied with systemic symptoms. Leprosy type 1 reaction often occurs in borderline leprosy patients. Leprosy type 1 reaction can cause peripheral nerve damage through neuritis that can lead to disability. Interferon-γ induced protein 10 (IP10) is a chemokine with chemotaxis function to various immune cells such as macrophage, dendritic cells, Natural Killer cells, and activated T lymphocites. Several studies have found an increase of IP10 serum level when type 1 reaction occurred.<br />
<strong>Purpose: </strong>To evaluate the profile of IP10 serum levels in borderline patients with and without type 1 leprosy reaction.<br />
<strong>Methods: </strong>This is a descriptive cross-sectional study, with 34 borderline leprosy patients of which 17 had leprosy type 1 reaction and 17 without reaction that qualify inclusion and exclusion criteria.<br />
<strong>Results: </strong>Mean serum IP10 levels in leprosy type 1 reaction groups are 594,123 ± 327,628 pg/mL and 331,648 ± 101,819 pg/mL in groups without reaction.<br />
<strong>Conclusions: </strong>Serum IP10 levels in borderline leprosy patient with type 1 reaction is higher than patients without reaction, although confounding factors in borderline leprosy patients with type 1 reaction that can influence serum IP10 levels cannot be eliminated. Further studies are needed to reveal the role of IP`10 in type 1 leprosy reaction.</p>
},
  year = {2017},
  journal = {Periodical of Dermatology and Venereology},
  volume = {29},
  pages = {212-219},
  url = {https://tinyurl.com/yd8cvoon},
  language = {eng},
}