@article{10372,
  keywords = {Antibodies, Anti-Idiotypic, Antigens, Bacterial, Arthritis, Rheumatoid, Autoimmune Diseases, DNA, DNA, Single-Stranded, Enzyme-Linked Immunosorbent Assay, Humans, Immunoglobulin Idiotypes, Immunoglobulins, Lupus Erythematosus, Systemic, Mycobacterium leprae, Reference Values, Rheumatic Diseases, Severity of Illness Index, Sjogren's Syndrome},
  author = {Williams W and Zumla A and Behrens R and Locniskar M and Voller A and McAdam K P and Isenberg D A},
  title = {Studies of a common idiotype PR4 in autoimmune rheumatic disease.},
  abstract = {<p>A new common idiotype, designated PR4, is described. This idiotype was originally identified on a human hybridoma-derived monoclonal antibody from a patient with leprosy, which binds the major Mycobacterium leprae-derived antigen, phenolic glycolipid-1, poly(ADP)-ribose, DNA, and poly(dT). The PR4 idiotype was found in patients with systemic lupus erythematosus (SLE) (70%), rheumatoid arthritis (40%), and Sjögren's syndrome (15%). It was not, however, found in the spouses of the SLE patients or (unlike other lupus idiotypes) in their healthy first-degree relatives. Although no correlation between PR4 idiotype levels and disease activity in SLE was found, a subset of rheumatoid arthritis patients with high levels of the idiotype was identified.</p>},
  year = {1988},
  journal = {Arthritis and rheumatism},
  volume = {31},
  pages = {1097-104},
  month = {1988 Sep},
  issn = {0004-3591},
  doi = {10.1002/art.1780310903},
  language = {eng},
}