Toll-like receptor 1 N248S single-nucleotide polymorphism is associated with leprosy risk and regulates immune activation during mycobacterial infection.

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TítuloToll-like receptor 1 N248S single-nucleotide polymorphism is associated with leprosy risk and regulates immune activation during mycobacterial infection.
Tipo de PublicaciónJournal Article
Autoresde Marques CS, Brito-de-Souza VN, Guerreiro LTA, Martins JH, Amaral EP, Cardoso CC, Dias-Batista IMF, da Silva WL, Nery JAC, Medeiros P, Gigliotti P, Campanelli AP, Virmond M, Sarno EN, Mira MT, Lana FCF, Caffarena ER, Pacheco AG, Pereira AC, Moraes MO
Abbrev. JournalJ. Infect. Dis.
RevistaThe Journal of infectious diseases
Año de Publicacion2013
Volume208
Issue1
Pagination120-9
Idioma de Publicacióneng
Palabras clave Adult, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Gene Frequency, Genotype, Haplotypes, Heterozygote, Humans, Immunity, Leprosy, Leukocytes, Mononuclear, Middle Aged, Mycobacterium leprae, Polymorphism, Single Nucleotide, Risk Factors, Toll-Like Receptor 1
Resumen

Conflicting findings about the association between leprosy and TLR1 variants N248S and I602S have been reported. Here, we performed case-control and family based studies, followed by replication in 2 case-control populations from Brazil, involving 3162 individuals. Results indicated an association between TLR1 248S and leprosy in the case-control study (SS genotype odds ratio [OR], 1.81; P = .004) and the family based study (z = 2.02; P = .05). This association was consistently replicated in other populations (combined OR, 1.51; P

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/23547143?dopt=Abstract

DOI10.1093/infdis/jit133
Shelf markSALESMARQUEZ213

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