Population survey to determine risk factors for Mycobacterium leprae transmission and infection.

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TítuloPopulation survey to determine risk factors for Mycobacterium leprae transmission and infection.
Tipo de PublicaciónJournal Article
AutoresBakker MI, Hatta M, Kwenang A, Faber WR, van Beers SM, Klatser PR, Oskam L
Abbrev. JournalInt J Epidemiol
RevistaInternational journal of epidemiology
Año de Publicacion2004
Volume33
Issue6
Pagination1329-36
Idioma de Publicacióneng
Palabras clave Adolescent, Adult, Antibodies, Bacterial, Child, Child, Preschool, Epidemiologic Methods, Female, Health Surveys, Humans, Indonesia, Leprosy, Male, Middle Aged, Mycobacterium leprae, Social Environment
Resumen

BACKGROUND: Not every leprosy patient is equally effective in transmitting Mycobacterium leprae. We studied the spatial distribution of infection (using seropositivity as a marker) in the population to identify which disease characteristics of leprosy patients are important in transmission.

METHODS: Clinical data and blood samples for anti-M. leprae ELISA were collected during a cross-sectional survey on five Indonesian islands highly endemic for leprosy. A geographic information system (GIS) was used to define contacts of patients. We investigated spatial clustering of patients and seropositive people and used logistic regression to determine risk factors for seropositivity.

RESULTS: Of the 3986 people examined for leprosy, 3271 gave blood. Seroprevalence varied between islands (1.7-8.7%) and correlated significantly with leprosy prevalence. Five clusters of patients and two clusters of seropositives were detected. In multivariate analysis, seropositivity significantly differed by leprosy status, age, sex, and island. Serological status of patients appeared to be the best discriminator of contact groups with higher seroprevalence: contacts of seropositive patients had an adjusted odds ratio (aOR) of 1.75 (95% CI 0.922-3.31). This increased seroprevalence was strongest for contact groups living

CONCLUSIONS: In this highly endemic area for leprosy, not only household contacts of seropositive patients, but also people living in the vicinity of a seropositive patient were more likely to harbour antibodies against M. leprae. Through measuring the serological status of patients and using a broader definition of contacts, higher risk groups can be more specifically identified.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/15256520?dopt=Abstract

DOI10.1093/ije/dyh266
Link to full texthttp://ije.oxfordjournals.org/content/33/6/1329.full.pdf+html
Shelf markBAKKER2004