Chemoprophylaxis is effective in the prevention of leprosy in endemic countries: a systematic review and meta-analysis. MILEP2 Study Group. Mucosal Immunology of Leprosy.

Printer-friendly version
TítuloChemoprophylaxis is effective in the prevention of leprosy in endemic countries: a systematic review and meta-analysis. MILEP2 Study Group. Mucosal Immunology of Leprosy.
Tipo de PublicaciónJournal Article
AutoresSmith CM, Smith WC
Abbrev. JournalJ. Infect.
RevistaThe Journal of infection
Año de Publicacion2000
Volume41
Issue2
Pagination137-42
Idioma de Publicacióneng
Palabras clave Acedapsone, Clinical Trials as Topic, Cost-Benefit Analysis, Dapsone, Humans, Leprostatic Agents, Leprosy, Rifampin, Risk Factors, Topography, Medical
Resumen

OBJECTIVE: To quantify the efficacy of chemoprophylaxis against leprosy.

METHOD: Literature searching of Medline and Embase databases, hand-searching of references and correspondence with investigators.

STUDY SELECTION: published papers relating to the prevention of leprosy and the use of chemotherapy in leprosy were identified for critical appraisal. Trials were selected and grouped into three categories according to study design and control groups.

DATA ANALYSIS: the relative risks (RR) with 95% confidence intervals were calculated from the original data using a random effects model. To assess the cost-effectiveness of chemoprophylaxis, a further analysis of the rates of disease in the trial and control groups was done based on the numbers needed to be treated (NNT) to prevent one new case of leprosy.

RESULTS: A total of 14 trials were identified from 127 published papers on chemoprophylaxis of leprosy. The trials were categorized into randomized controlled trials, non-randomized controlled trials, and uncontrolled trials. The overall results of the meta-analysis shows that chemoprophylaxis gives around 60% protection against leprosy. The NNT are low in trials of household contacts.

CONCLUSIONS: The evidence shows that chemoprophylaxis against leprosy is an effective way to reduce the incidence of leprosy, particularly in household contacts. The role of chemoprophylaxis needs to be re-examined using newer drugs given the continuing case detection rates globally.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/11023757?dopt=Abstract

DOI10.1053/jinf.2000.0698
Shelf markSMITH 2000C