TY - JOUR KW - Adult KW - Antimony Sodium Gluconate KW - Child KW - Child, Preschool KW - Female KW - Humans KW - Leishmaniasis, Cutaneous KW - Leishmaniasis, Visceral KW - Male KW - Treatment Outcome AU - Hassan A M AU - Ghalib H W AU - Zijlstra E E AU - Eltoum I A AU - Satti M AU - Ali M S AU - Ali H M AB -

The clinical features, pathology, immune responses, diagnosis and treatment of post kala-azar dermal leishmaniasis (PKDL) in the Sudan are described and discussed. The disease is characterized by maculopapular or nodular lesions on the face, limbs or trunk. Lesions appear during or within months after the treatment of visceral leishmaniasis, but in 2 of 19 patients there was no previous history of kala-azar. PKDL may be confused with leprosy both clinically and pathologically. Similarities and differences between the 2 diseases are discussed. Unlike visceral leishmaniasis, the peripheral lymphoid cells of patients with PKDL respond to Leishmania antigen and some are leishmanin positive. The response to intravenous sodium stibogluconate (20 mg/kg for 30 d) was reasonably good but some patients required repeated or more prolonged treatment. Ketoconazole in a dose of 10 mg/kg daily for 4 weeks had no effect on PKDL.

BT - Transactions of the Royal Society of Tropical Medicine and Hygiene C1 - http://www.ncbi.nlm.nih.gov/pubmed/1329273?dopt=Abstract DA - 1992 May-Jun DO - 10.1016/0035-9203(92)90294-m IS - 3 J2 - Trans. R. Soc. Trop. Med. Hyg. LA - eng N2 -

The clinical features, pathology, immune responses, diagnosis and treatment of post kala-azar dermal leishmaniasis (PKDL) in the Sudan are described and discussed. The disease is characterized by maculopapular or nodular lesions on the face, limbs or trunk. Lesions appear during or within months after the treatment of visceral leishmaniasis, but in 2 of 19 patients there was no previous history of kala-azar. PKDL may be confused with leprosy both clinically and pathologically. Similarities and differences between the 2 diseases are discussed. Unlike visceral leishmaniasis, the peripheral lymphoid cells of patients with PKDL respond to Leishmania antigen and some are leishmanin positive. The response to intravenous sodium stibogluconate (20 mg/kg for 30 d) was reasonably good but some patients required repeated or more prolonged treatment. Ketoconazole in a dose of 10 mg/kg daily for 4 weeks had no effect on PKDL.

PY - 1992 SP - 245 EP - 8 T2 - Transactions of the Royal Society of Tropical Medicine and Hygiene TI - Post kala-azar dermal leishmaniasis in the Sudan: clinical features, pathology and treatment. VL - 86 SN - 0035-9203 ER -