Helper T lymphocytes can only recognize mycobacterial antigens when they are presented by HLA class 2 molecules. Thus, these molecules may play an important role in the regulation of the immune response against mycobacteria. In this paper it is demonstrated that the T cells from individuals with different HLA class 2 molecules react to different mycobacterial antigens. These data indicate that HLA class 2 molecules are the products of immune response (Ir) genes for mycobacteria. Such genetically controlled differences in antimycobacterial T cell reactivity may explain the association of certain HLA class 2 alleles with a different course of mycobacterial infections and may have implications for vaccine development.
BT - Reviews of infectious diseases C1 - http://www.ncbi.nlm.nih.gov/pubmed/2496455?dopt=Abstract DA - 1989 Mar-Apr DO - 10.1093/clinids/11.supplement_2.s400 J2 - Rev. Infect. Dis. LA - eng N2 -Helper T lymphocytes can only recognize mycobacterial antigens when they are presented by HLA class 2 molecules. Thus, these molecules may play an important role in the regulation of the immune response against mycobacteria. In this paper it is demonstrated that the T cells from individuals with different HLA class 2 molecules react to different mycobacterial antigens. These data indicate that HLA class 2 molecules are the products of immune response (Ir) genes for mycobacteria. Such genetically controlled differences in antimycobacterial T cell reactivity may explain the association of certain HLA class 2 alleles with a different course of mycobacterial infections and may have implications for vaccine development.
PY - 1989 SP - S400 EP - 3 T2 - Reviews of infectious diseases TI - Regulation of T cell responsiveness against mycobacterial antigens by HLA class 2 immune response genes. VL - 11 Suppl 2 SN - 0162-0886 ER -