TY - JOUR KW - Adolescent KW - Adult KW - Aged KW - Autoantibodies KW - Blood Coagulation Factors KW - Cardiolipins KW - Child KW - DNA KW - Endocarditis, Bacterial KW - Enzyme-Linked Immunosorbent Assay KW - Female KW - Humans KW - Infection KW - leprosy KW - Lupus Coagulation Inhibitor KW - Male KW - Middle Aged KW - Tuberculosis AU - Santiago M B AU - COSSERMELLI W AU - Tuma M F AU - Pinto M N AU - Oliveira R M AB -

IgG or IgM anticardiolipin antibodies were present in the sera of 67% of 33 patients with Hansen's disease, in 53% of 30 patients with tuberculosis and in 50% of 16 patients with endocarditis. Despite the high frequency of these antibodies, no patient had a history of thrombosis or abortion. Anti-denatured DNA antibodies were tested in patients with tuberculosis and patients with Hansen's disease. Only in the latter group did we observe a statistically significant association between anticardiolipin and anti-denatured DNA antibodies. Anticardiolipin binding activity, however, could not be inhibited by preincubation of sera with a variable concentration of denatured DNA. These data suggest that: a) Anticardiolipin antibodies in infectious diseases do not necessarily participate in the pathogenesis of thrombotic or obstetric complications; b) Anti-denatured DNA and anticardiolipin antibodies in the population studied do not have a cross-reaction.

BT - Clinical rheumatology C1 - http://www.ncbi.nlm.nih.gov/pubmed/2501063?dopt=Abstract DA - 1989 Mar DO - 10.1007/bf02031064 IS - 1 J2 - Clin. Rheumatol. LA - eng N2 -

IgG or IgM anticardiolipin antibodies were present in the sera of 67% of 33 patients with Hansen's disease, in 53% of 30 patients with tuberculosis and in 50% of 16 patients with endocarditis. Despite the high frequency of these antibodies, no patient had a history of thrombosis or abortion. Anti-denatured DNA antibodies were tested in patients with tuberculosis and patients with Hansen's disease. Only in the latter group did we observe a statistically significant association between anticardiolipin and anti-denatured DNA antibodies. Anticardiolipin binding activity, however, could not be inhibited by preincubation of sera with a variable concentration of denatured DNA. These data suggest that: a) Anticardiolipin antibodies in infectious diseases do not necessarily participate in the pathogenesis of thrombotic or obstetric complications; b) Anti-denatured DNA and anticardiolipin antibodies in the population studied do not have a cross-reaction.

PY - 1989 SP - 23 EP - 8 T2 - Clinical rheumatology TI - Anticardiolipin antibodies in patients with infectious diseases. VL - 8 SN - 0770-3198 ER -