TY - JOUR
KW - Follicle Stimulating Hormone
KW - Humans
KW - Hypogonadism
KW - leprosy
KW - Luteinizing Hormone
KW - Male
KW - Random Allocation
KW - Testosterone
AU - Levis W R
AU - Lanza A P
AU - Swersie S
AU - Meeker H C
AU - Schuller-Levis G B
AU - Bardin C W
AB - <p>Luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone levels were determined by radioimmunoassay (RIA) in leprosy patients and analysed for effect of disease classification, disease activity and duration of disease. LH and FSH levels were found to be significantly elevated in lepromatous patients compared to borderline-lepromatous, midborderline and borderline-tuberculoid patients. A positive correlation was seen between LH and FSH and a negative correlation was seen between testosterone and both LH and FSH. No correlation was seen between hormone levels and measures of disease activity: bacillary index and IgM to phenolic glycolipid I, a Mycobacterium leprae antigen. A significant correlation was seen between duration of disease and FSH when age was taken into account, indicating that testicular dysfunction is probably cumulative and irreversible. It is recommended that LL patients be routinely screened for hypogonadism using FSH, LH and testosterone levels.</p>
BT - Leprosy review
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2505006?dopt=Abstract
CN - LEVIS1989
DA - 1989 Jun
DO - 10.5935/0305-7518.19890012
IS - 2
J2 - Lepr Rev
LA - eng
N2 - <p>Luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone levels were determined by radioimmunoassay (RIA) in leprosy patients and analysed for effect of disease classification, disease activity and duration of disease. LH and FSH levels were found to be significantly elevated in lepromatous patients compared to borderline-lepromatous, midborderline and borderline-tuberculoid patients. A positive correlation was seen between LH and FSH and a negative correlation was seen between testosterone and both LH and FSH. No correlation was seen between hormone levels and measures of disease activity: bacillary index and IgM to phenolic glycolipid I, a Mycobacterium leprae antigen. A significant correlation was seen between duration of disease and FSH when age was taken into account, indicating that testicular dysfunction is probably cumulative and irreversible. It is recommended that LL patients be routinely screened for hypogonadism using FSH, LH and testosterone levels.</p>
PY - 1989
SP - 94
EP - 101
T2 - Leprosy review
TI - Testicular dysfunction in leprosy: relationships of FSH, LH and testosterone to disease classification, activity and duration.
UR - http://leprev.ilsl.br/pdfs/1989/v60n2/pdf/v60n2a02.pdf
VL - 60
SN - 0305-7518
ER -