The bacillus Mycobacterium leprae causes leprosy, a chronic granulomatous disease. Skin and nerves are primarily affected and still endemic in various regions of the planet. It is important to note that the patient’s immune status can influence the disease’s clinical presentation. Leprosy is a disease that is associated with physical impairment and social exclusion. Patients with at least one of the World Health Organization’s cardinal signs—hypopigmented or erythematous macules with sensory loss, thickened peripheral nerves, or positive acid-fast smear or skin biopsy with loss of adnexa at affected sites—will have their diagnosis made based on clinical findings alone.
Rifampicin, clofazimine, and dapsone are used to treat leprosy. It is necessary to use one of two main regimens based on whether the patient has paucibacillary or multibacillary disease
BT - Viral, Parasitic, Bacterial, and Fungal Infections DO - 10.1016/b978-0-323-85730-7.00042-4 LA - Eng N2 -
The bacillus Mycobacterium leprae causes leprosy, a chronic granulomatous disease. Skin and nerves are primarily affected and still endemic in various regions of the planet. It is important to note that the patient’s immune status can influence the disease’s clinical presentation. Leprosy is a disease that is associated with physical impairment and social exclusion. Patients with at least one of the World Health Organization’s cardinal signs—hypopigmented or erythematous macules with sensory loss, thickened peripheral nerves, or positive acid-fast smear or skin biopsy with loss of adnexa at affected sites—will have their diagnosis made based on clinical findings alone.
Rifampicin, clofazimine, and dapsone are used to treat leprosy. It is necessary to use one of two main regimens based on whether the patient has paucibacillary or multibacillary disease
PB - Elsevier PY - 2023 SN - 9780323857307 SP - 609 EP - 615 T2 - Viral, Parasitic, Bacterial, and Fungal Infections TI - Pathogenesis, clinical manifestations, and treatment of leprosy ER -