Type 1 lepra reaction (T1R) is a major complication seen in nonpolar forms of leprosy and leads to significant morbidity. The classification of T1R as up and downgrading, based on previously defined histopathological criteria (by Ridley), has therapeutic and prognostic implications. The trigger factors for these reactions are poorly described, especially in case of downgrading T1R and we describe a case of leprosy reaction that was possibly triggered by chemoradiation and elucidate the possible mechanism.
BT - The American journal of tropical medicine and hygiene C1 -https://www.ncbi.nlm.nih.gov/pubmed/35895355
DA - 07/2022 DO - 10.4269/ajtmh.22-0099 IS - 1 J2 - Am J Trop Med Hyg LA - eng N2 -Type 1 lepra reaction (T1R) is a major complication seen in nonpolar forms of leprosy and leads to significant morbidity. The classification of T1R as up and downgrading, based on previously defined histopathological criteria (by Ridley), has therapeutic and prognostic implications. The trigger factors for these reactions are poorly described, especially in case of downgrading T1R and we describe a case of leprosy reaction that was possibly triggered by chemoradiation and elucidate the possible mechanism.
PY - 2022 SP - 94 EP - 96 T2 - The American journal of tropical medicine and hygiene TI - Case Report: Chemoradiation with Paclitaxel and Carboplatin Unveiling Leprosy Type 1 Downgrading Reaction. VL - 107 SN - 1476-1645 ER -