, the etiologic agent of leprosy, is an acid-fast-staining and slow-growing bacilli that infect macrophages and Schwann cells individually or through forming globi. The clinical presentation of leprosy is broad and depends on the host immune response. We report a case of a 42-year-old Brazilian man presenting with fever of unknown origin (FUO), anemia, wasting syndrome, and neuropathy. The diagnosis of lepromatous leprosy was made after an extensive investigation revealed the presence of in the bone marrow. Bone marrow involvement in leprosy is rare and some authors believe the presence of in the bone marrow can act as a reservoir of the disease facilitating future relapses. It is important to investigate bone marrow involvement in leprosy, especially when the patient presents with cytopenias and positive epidemiologic history.
BT - Frontiers in immunology C1 -https://www.ncbi.nlm.nih.gov/pubmed/35874693
DA - 01/2022 DO - 10.3389/fimmu.2022.916319 J2 - Front Immunol LA - eng N2 -, the etiologic agent of leprosy, is an acid-fast-staining and slow-growing bacilli that infect macrophages and Schwann cells individually or through forming globi. The clinical presentation of leprosy is broad and depends on the host immune response. We report a case of a 42-year-old Brazilian man presenting with fever of unknown origin (FUO), anemia, wasting syndrome, and neuropathy. The diagnosis of lepromatous leprosy was made after an extensive investigation revealed the presence of in the bone marrow. Bone marrow involvement in leprosy is rare and some authors believe the presence of in the bone marrow can act as a reservoir of the disease facilitating future relapses. It is important to investigate bone marrow involvement in leprosy, especially when the patient presents with cytopenias and positive epidemiologic history.
PY - 2022 EP - 916319 T2 - Frontiers in immunology TI - Fever of Unknown Origin, Wasting Syndrome and Bone Marrow Involvement: A Leprosy Case Report. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300819/pdf/fimmu-13-916319.pdf VL - 13 SN - 1664-3224 ER -