TY - JOUR KW - Epidermal Cells KW - HLA-DR Antigens KW - Humans KW - Interferon-gamma KW - Interleukin-1 KW - Interleukin-2 KW - Keratins KW - leprosy KW - Macrophages KW - Receptors, Antigen, T-Cell KW - Receptors, Immunologic KW - Receptors, Interleukin-2 KW - Skin AU - Volc-Platzer B AU - Stemberger H AU - Luger T AU - Radaszkiewicz T AU - Wiedermann G AB -

Cryostat sections of full-thickness skin biopsies from 21 patients along the whole spectrum of leprosy were subjected to immunohistological examination with special regard to defective lymphokine production. There was an inverse relationship between intra-lesional IL-1 reactivity and IL-2R expression, in that the latter was markedly observed in tuberculoid lesions. Whenever epithelioid cell containing granulomas were present in paucibacillary forms, significant reactivity within the central phagocytic cells with the monoclonal antibody directed against interferon-gamma was detectable. The keratinocytes covering tuberculoid lesions abundantly expressed class II alloantigens (HLA-DR antigens), indicating high intra-lesional interferon-gamma activity. In contrast, multibacillary forms revealed significant anti-IL-1 reactivity within the cellular infiltrate. IL-2R bearing cells were virtually absent as was anti-HLA-DR reactivity of the keratinocytes, underlining a defective intra-lesional interferon-gamma activity.

BT - Clinical and experimental immunology C1 - http://www.ncbi.nlm.nih.gov/pubmed/2450707?dopt=Abstract DA - 1988 Feb IS - 2 J2 - Clin. Exp. Immunol. LA - eng N2 -

Cryostat sections of full-thickness skin biopsies from 21 patients along the whole spectrum of leprosy were subjected to immunohistological examination with special regard to defective lymphokine production. There was an inverse relationship between intra-lesional IL-1 reactivity and IL-2R expression, in that the latter was markedly observed in tuberculoid lesions. Whenever epithelioid cell containing granulomas were present in paucibacillary forms, significant reactivity within the central phagocytic cells with the monoclonal antibody directed against interferon-gamma was detectable. The keratinocytes covering tuberculoid lesions abundantly expressed class II alloantigens (HLA-DR antigens), indicating high intra-lesional interferon-gamma activity. In contrast, multibacillary forms revealed significant anti-IL-1 reactivity within the cellular infiltrate. IL-2R bearing cells were virtually absent as was anti-HLA-DR reactivity of the keratinocytes, underlining a defective intra-lesional interferon-gamma activity.

PY - 1988 SP - 235 EP - 40 T2 - Clinical and experimental immunology TI - Defective intralesional interferon-gamma activity in patients with lepromatous leprosy. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541447/pdf/clinexpimmunol00101-0031.pdf VL - 71 SN - 0009-9104 ER -