TY - JOUR
KW - Animals
KW - Antigens, Bacterial
KW - Antigens, Differentiation, T-Lymphocyte
KW - Cells, Cultured
KW - Cytotoxicity, Immunologic
KW - Epitopes
KW - Mice
KW - Mice, Inbred C57BL
KW - Mycobacterium leprae
KW - Phenotype
KW - Schwann Cells
KW - T-Lymphocytes, Cytotoxic
AU - Steinhoff U
AU - Kaufmann S H
AB - <p>In vitro cultured murine Schwann cells which were devoid of class I and class II gene products of the major histocompatibility complex expressed class I, though not class II, antigens after stimulation with recombinant interferon-gamma. Recombinant IFN-gamma-stimulated Schwann cells after priming with M. leprae were lysed by antigen-specific CD8+ T lymphocytes in vitro. These findings suggest that specific lysis of M. leprae-infected Schwann cells by CD8+ CTL plays a role in leprosy.</p>
BT - European journal of immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2454827?dopt=Abstract
DA - 1988 Jun
DO - 10.1002/eji.1830180622
IS - 6
J2 - Eur. J. Immunol.
LA - eng
N2 - <p>In vitro cultured murine Schwann cells which were devoid of class I and class II gene products of the major histocompatibility complex expressed class I, though not class II, antigens after stimulation with recombinant interferon-gamma. Recombinant IFN-gamma-stimulated Schwann cells after priming with M. leprae were lysed by antigen-specific CD8+ T lymphocytes in vitro. These findings suggest that specific lysis of M. leprae-infected Schwann cells by CD8+ CTL plays a role in leprosy.</p>
PY - 1988
SP - 969
EP - 72
T2 - European journal of immunology
TI - Specific lysis by CD8+ T cells of Schwann cells expressing Mycobacterium leprae antigens.
VL - 18
SN - 0014-2980
ER -