Besides its role in multidrug therapy, clofazimine at higher doses is widely used for relief of Type 2 (ENL) reaction in leprosy. There is a lack of evidence from clinical trials regarding indications, optimum regimen and risk/benefit ratio to support published guidelines on its use as an anti-reaction drug. Clinical experience suggests that in adults it is safe at high doses (up to 300 mg/day) for limited periods of time but caution is needed with patients of low body weight and in those taking other drugs which may interact.
BT - Leprosy Review DO - 10.47276/lr.92.4.427 IS - 4 LA - eng N2 -Besides its role in multidrug therapy, clofazimine at higher doses is widely used for relief of Type 2 (ENL) reaction in leprosy. There is a lack of evidence from clinical trials regarding indications, optimum regimen and risk/benefit ratio to support published guidelines on its use as an anti-reaction drug. Clinical experience suggests that in adults it is safe at high doses (up to 300 mg/day) for limited periods of time but caution is needed with patients of low body weight and in those taking other drugs which may interact.
PB - Lepra PY - 2021 SP - 427 EP - 432 T2 - Leprosy Review TI - Benefits of high dose clofazimine UR - https://leprosyreview.org/admin/public/api/lepra/website/getDownload/61b86d62afaac16e5e22b35d VL - 92 SN - 2162-8807 ER -