Mycobacteriosis, mostly resulting from (MTb), nontuberculous mycobacteria (NTM), and (), is the long-standing granulomatous disease that ravages several organs including skin, lung, and peripheral nerves, and it has a spectrum of clinical-pathologic features based on the interaction of bacilli and host immune response. Histiocytes in infectious granulomas mainly consist of infected and uninfected macrophages (Mφs), multinucleated giant cells (MGCs), epithelioid cells (ECs), and foam cells (FCs), which are commonly discovered in lesions in patients with mycobacteriosis. Granuloma Mφ polarization or reprogramming is the crucial appearance of the host immune response to pathogen aggression, which gets a command of endocellular microbe persistence. Herein, we recapitulate the current gaps and challenges during Mφ polarization and the different subpopulations of mycobacteriosis.
BT - Frontiers in immunology C1 -https://www.ncbi.nlm.nih.gov/pubmed/34899703
DA - 01/2021 DO - 10.3389/fimmu.2021.752657 J2 - Front Immunol LA - eng N2 -Mycobacteriosis, mostly resulting from (MTb), nontuberculous mycobacteria (NTM), and (), is the long-standing granulomatous disease that ravages several organs including skin, lung, and peripheral nerves, and it has a spectrum of clinical-pathologic features based on the interaction of bacilli and host immune response. Histiocytes in infectious granulomas mainly consist of infected and uninfected macrophages (Mφs), multinucleated giant cells (MGCs), epithelioid cells (ECs), and foam cells (FCs), which are commonly discovered in lesions in patients with mycobacteriosis. Granuloma Mφ polarization or reprogramming is the crucial appearance of the host immune response to pathogen aggression, which gets a command of endocellular microbe persistence. Herein, we recapitulate the current gaps and challenges during Mφ polarization and the different subpopulations of mycobacteriosis.
PY - 2021 EP - 752657 T2 - Frontiers in immunology TI - Progress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660122/pdf/fimmu-12-752657.pdf VL - 12 SN - 1664-3224 ER -