TY - JOUR
KW - Antigen-Antibody Complex
KW - Blood Proteins
KW - Chemical Precipitation
KW - Complement Activation
KW - Complement Hemolytic Activity Assay
KW - Complement Pathway, Alternative
KW - Erythema Nodosum
KW - Humans
KW - leprosy
KW - Leprosy, Borderline
KW - Leprosy, lepromatous
KW - Leprosy, Tuberculoid
KW - Polyethylene Glycols
AU - Tyagi P
AU - Ramanathan V D
AU - Girdhar B K
AU - Katoch K
AU - Bhatia A S
AU - Sengupta U
AB - <p>Circulating immune complexes isolated from different types of leprosy sera as polyethylene glycol (PEG) precipitates were found to be efficient activators of the alternative pathway of complement. PEG precipitates from BL/LL leprosy patients and those with erythema nodosum leprosum were found to activate both the classical pathway and the alternative pathway of complement efficiently, while PEG precipitates from TT/BT leprosy patients and borderline tuberculoid patients in reaction were found to active the alternative pathway of complement but not the classical pathway. No significant differences were observed between the PEG precipitates from reactional and nonreactional TT/BT and BL/LL patients in their complement activating ability.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2319186?dopt=Abstract
CN - TYAGI1990
DA - 1990 Mar
IS - 1
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>Circulating immune complexes isolated from different types of leprosy sera as polyethylene glycol (PEG) precipitates were found to be efficient activators of the alternative pathway of complement. PEG precipitates from BL/LL leprosy patients and those with erythema nodosum leprosum were found to activate both the classical pathway and the alternative pathway of complement efficiently, while PEG precipitates from TT/BT leprosy patients and borderline tuberculoid patients in reaction were found to active the alternative pathway of complement but not the classical pathway. No significant differences were observed between the PEG precipitates from reactional and nonreactional TT/BT and BL/LL patients in their complement activating ability.</p>
PY - 1990
SP - 31
EP - 8
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - Activation of complement by circulating immune complexes isolated from leprosy patients.
UR - http://ila.ilsl.br/pdfs/v58n1a05.pdf
VL - 58
SN - 0148-916X
ER -