TY - JOUR
AU - Kadam AD
AU - Khopade DM
AB - <jats:p>Objective: In several countries, including India, leprosy is an older disease &amp; till now continues to be an important health issue. Leprosy is a chronic granulomatous disease, the contributing agent for this is mycobacterium leprae. Nitric oxide (NO) plays a significant role in immunity to fight against bacteria. But increased NO can harm host tissue by causing altered structure of thiol-containing compounds, which is a significant event that influences the pathogenesis of leprosy. Considering this, the study was planned to determine the type of relationship between NO, nitrothiols, and thiols as disease advances.&#x0D;
Methods: 50 newly diagnosed leprosy patients &amp; 50 healthy controls were included in the study. In the leprosy group,16 were Paucibacillary (PB), and 34 were Multibacillary (MB) type, leprosy patients.&#x0D;
Results: Serum NO and serum nitrothiol significantly increased (p&lt;0.01) in leprosy patients than controls. Further, Serum NO and serum nitrothiol significantly increased (p&lt;0.01) in MB leprosy patients than PB leprosy patients. On the other hand, we found a significantly decreased (p&lt;0.01) level of total thiols in leprosy patients compared with controls. Serum thiols  significantly decreased (p&lt;0.01) in MB leprosy patients than PB leprosy patients. Among Both leprosy patients, the negative correlation of NO with thiol and nitrothiol with thiols was observed.&#x0D;
Conclusion: Thus, in leprosy, increased nitric oxide causes modification of thiol groups of proteins and impaired their activity which may be responsible for the severity of disease; hence therapy aimed to reduce nitrosative modification of proteins leprosy.</jats:p>
BT - Journal of Pharmaceutical Research International
DO - 10.9734/jpri/2021/v33i35a31872
LA - eng
N2 - <jats:p>Objective: In several countries, including India, leprosy is an older disease &amp; till now continues to be an important health issue. Leprosy is a chronic granulomatous disease, the contributing agent for this is mycobacterium leprae. Nitric oxide (NO) plays a significant role in immunity to fight against bacteria. But increased NO can harm host tissue by causing altered structure of thiol-containing compounds, which is a significant event that influences the pathogenesis of leprosy. Considering this, the study was planned to determine the type of relationship between NO, nitrothiols, and thiols as disease advances.&#x0D;
Methods: 50 newly diagnosed leprosy patients &amp; 50 healthy controls were included in the study. In the leprosy group,16 were Paucibacillary (PB), and 34 were Multibacillary (MB) type, leprosy patients.&#x0D;
Results: Serum NO and serum nitrothiol significantly increased (p&lt;0.01) in leprosy patients than controls. Further, Serum NO and serum nitrothiol significantly increased (p&lt;0.01) in MB leprosy patients than PB leprosy patients. On the other hand, we found a significantly decreased (p&lt;0.01) level of total thiols in leprosy patients compared with controls. Serum thiols  significantly decreased (p&lt;0.01) in MB leprosy patients than PB leprosy patients. Among Both leprosy patients, the negative correlation of NO with thiol and nitrothiol with thiols was observed.&#x0D;
Conclusion: Thus, in leprosy, increased nitric oxide causes modification of thiol groups of proteins and impaired their activity which may be responsible for the severity of disease; hence therapy aimed to reduce nitrosative modification of proteins leprosy.</jats:p>
PB - Sciencedomain International
PY - 2021
SP - 45
EP - 50
T2 - Journal of Pharmaceutical Research International
TI - Study of Effect of Nitrosamine Stress in Progression of Leprosy
UR - https://journaljpri.com/index.php/JPRI/article/view/31872/59879
SN - 2456-9119
ER -