Cell-mediated and humoral immunity were studied in 25 children between 0 and 14 years with leprosy. Cell-mediated immunity was studied in vivo by lepromin and epicutaneous sensitization with dinitrochlorobenzene (DNCB) and T-lymphocytes and their subpopulations (T4 and T8) in the peripheral blood. Humoral immunity was evaluated by B-lymphocyte count and immunoglobulins (IgG, IgM and IgA). Along with complement, component C3 was also measured in the serum. Lepromin (Mitsuda) and DNCB responses were significantly poor in mid-borderline (BB) leprosy. The hematological profile, including T-lymphocytes, their subpopulations, B-lymphocytes, serum immunoglobulins, and C3, were found to be normal in all forms of leprosy. The relatively short duration of disease and the low bacterial load may explain these findings.
BT - The Journal of dermatology C1 - http://www.ncbi.nlm.nih.gov/pubmed/2384638?dopt=Abstract CN - SEHGAL1990 DA - 1990 Jun DO - 10.1111/j.1346-8138.1990.tb01656.x IS - 6 J2 - J. Dermatol. LA - eng N2 -Cell-mediated and humoral immunity were studied in 25 children between 0 and 14 years with leprosy. Cell-mediated immunity was studied in vivo by lepromin and epicutaneous sensitization with dinitrochlorobenzene (DNCB) and T-lymphocytes and their subpopulations (T4 and T8) in the peripheral blood. Humoral immunity was evaluated by B-lymphocyte count and immunoglobulins (IgG, IgM and IgA). Along with complement, component C3 was also measured in the serum. Lepromin (Mitsuda) and DNCB responses were significantly poor in mid-borderline (BB) leprosy. The hematological profile, including T-lymphocytes, their subpopulations, B-lymphocytes, serum immunoglobulins, and C3, were found to be normal in all forms of leprosy. The relatively short duration of disease and the low bacterial load may explain these findings.
PY - 1990 SP - 356 EP - 61 T2 - The Journal of dermatology TI - Cell-mediated and humoral immunity in leprosy in children. VL - 17 SN - 0385-2407 ER -