TY - JOUR KW - Clofazimine KW - Dapsone KW - Drug Combinations KW - Ethionamide KW - Female KW - Humans KW - leprosy KW - Male KW - Recurrence KW - Rifampin AU - Flageul B AU - Vignon-Pennamen M D AU - Wallach D AU - Pennec J AU - Cottenot F AB -

Since the application of short duration multidrug therapy (MDT) in leprosy, it has been reported that reversal reactions (RR) may occur after withdrawal of treatment. Surprisingly, such "late reversal reactions" have quite never been described after monosulphonotherapy. Such RR, especially in endemic areas, may represent diagnostic and therapeutic difficult problems. We report 5 cases of late RR. In 4 cases (1 BT patient and 3 BL-LLs patients), the RR occurred 1 month 1/2 to 3 years after cessation of MDT. In the last case (form LLs), the RR happened 6 months after that a 14 years monosulphonotherapy has been stopped. These observations strengthen the need of a complete clinical, bacteriological and immunological evaluation at the time of the diagnostic, more useful than a single bacteriological study, to differentiate late RR from relapses. Moreover, the last case confirms that late RR may occur after monosulphonotherapy.

BT - Acta leprologica C1 - http://www.ncbi.nlm.nih.gov/pubmed/2220295?dopt=Abstract DA - 1990 IS - 2 J2 - Acta Leprol LA - fre N2 -

Since the application of short duration multidrug therapy (MDT) in leprosy, it has been reported that reversal reactions (RR) may occur after withdrawal of treatment. Surprisingly, such "late reversal reactions" have quite never been described after monosulphonotherapy. Such RR, especially in endemic areas, may represent diagnostic and therapeutic difficult problems. We report 5 cases of late RR. In 4 cases (1 BT patient and 3 BL-LLs patients), the RR occurred 1 month 1/2 to 3 years after cessation of MDT. In the last case (form LLs), the RR happened 6 months after that a 14 years monosulphonotherapy has been stopped. These observations strengthen the need of a complete clinical, bacteriological and immunological evaluation at the time of the diagnostic, more useful than a single bacteriological study, to differentiate late RR from relapses. Moreover, the last case confirms that late RR may occur after monosulphonotherapy.

PY - 1990 SP - 109 EP - 17 T2 - Acta leprologica TI - [Late reversal reactions in leprosy]. VL - 7 SN - 0001-5938 ER -