TY - JOUR
KW - Animals
KW - Cell Division
KW - Chronic Disease
KW - Disease Models, Animal
KW - Histocytochemistry
KW - Immunologic Deficiency Syndromes
KW - leprosy
KW - Macrophages
KW - Mice
KW - Mycobacterium leprae
KW - Peritoneal Cavity
KW - Time Factors
AU - Vishnevetskiĭ F E
AU - Freĭdlin I S
AU - Iushin IM
AU - Urliapova N G
AB - <p>The dynamics of mycobacterial multiplication was followed in mice with intraplantar leprosy infection and preinduced macrophage insufficiency. The characteristics of Shepard's model appeared to be similar to those of the method proposed by the authors including the susceptibility to the main antileprosy drugs. Peritoneal macrophages were cytochemically studied in the process of development of mononuclear phagocyte deficiency and experimental leprosy. It was concluded that the method proposed preserving all the merits of Shepard's model should allow one to shorten significantly the duration of testing potential drugs for their antileprosy activity.</p>
BT - Arkhiv patologii
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2222222?dopt=Abstract
DA - 1990
IS - 6
J2 - Arkh. Patol.
LA - rus
N2 - <p>The dynamics of mycobacterial multiplication was followed in mice with intraplantar leprosy infection and preinduced macrophage insufficiency. The characteristics of Shepard's model appeared to be similar to those of the method proposed by the authors including the susceptibility to the main antileprosy drugs. Peritoneal macrophages were cytochemically studied in the process of development of mononuclear phagocyte deficiency and experimental leprosy. It was concluded that the method proposed preserving all the merits of Shepard's model should allow one to shorten significantly the duration of testing potential drugs for their antileprosy activity.</p>
PY - 1990
SP - 46
EP - 50
T2 - Arkhiv patologii
TI - [The modelling of chronic infection (experimental leprosy) against a background of macrophagal immunodeficiency].
VL - 52
SN - 0004-1955
ER -